1974-76,  Postdoctoral, Dept. of Biological Chemistry, Washington University Medical School
1970-73,  Ph.D., Biochemistry, Michigan State University
1966-70,  B.S. (Major: Chemistry; Minor: Mathematics), University of Pittsburgh

Dr.Schroeder's laboratory's research interests focus on basic problems of the transfer of proteins, lipids, and xenobiotics within the cell. The basic concepts and technologies derived therefrom have broad application to Cardiovascular Science, Pathobiology of Host-Pathogen Interactions, and Environmental Toxicology.

A. Molecular biology of lipid transfer proteins.
   1. Intracellular lipid transfer proteins: fatty acid binding proteins (FABP), sterol carrier proteins (SCP), and fatty acyl CoA binding proteins (ACBP)]
   2. Recombinant technology in mammalian cell transfection, gene ablation.

B. Function of lipid transfer proteins in transfected intact cells.
   1. Role(s) of FABP/SCP/ACBP in cholesterol, fatty acid, and fatty acyl CoA intracellular transfer and targeting to specific metabolic pathways.
   2. Modulation of lipid domains in cellular membranes by lipid transfer proteins.
   3. Role of lipid domains and transfer proteins in lipid efflux and intracellular distribution.

C. Structural biology and molecular modeling of lipid transfer protein ligand interaction.
   1. Lipid protein interactions: Fatty acid, fatty acyl CoA, and sterol binding site(s) of cytosolic lipid transfer proteins.
   2. Silicon graphics molecular modeling of intracellular lipid transfer proteins structure based on fluorescence, CD, X ray and NMR.
   3. Multifrequency phase fluorometry, photon counting steady state fluorometry, and circular dichroism in determining protein structure and protein-ligand interaction.
   4. Multiphoton Excitation Laser Scanning Microscopy and Confocal Laser Scanning Microscopy: examination of intracellular fluorescent fatty acid and fluorescent sterol trafficking; targeting of proteins to intracellular organelles.

D. Membrane Protein Lipid Domain Interactions.
   1. Biochemical & biophysical investigations on role of membrane lipid asymmetry and lipid domains in transmembrane receptor function coupling and regulation.
   2. Role of plasma membrane caveolae microdomains in intracellular lipid transport.
   3. Use of fluorescence probes, Multifrequency (1 250 MHz) Phase and Modulation Fluorometry, Circular Dichroism, Fluorescence Photobleaching Recovery to determine physical properties of membranes and lipoproteins.
   4. Mechanism of action of viral entry into cells and pathogenesis.

1969-1970, Undergraduate Res. Assistant, Univ. of Pittsburgh, Pittsburgh, PA. "Use of a Gas Density Balance for Low Molecular Weight Determinations," under Dr. J. Carter.

1970-1974, NSF Graduate Fellow, Michigan State University, East Lansing, MI. "Mechanism of Action of Polyene Antibiotics," with Dr. L.L. Bieber, Thesis Advisor.

1974-1976, ACS Postdoctoral Fellow, Washington Univ. School of Medicine, St. Louis, MO. "Membrane Structure and Function," with Dr. P. Roy Vagelos, Post Doctoral Advisor.

1976-1982, Assistant Prof. of Pharmacology, Univ. Missouri Sch. of Medicine, Columbia, MO.

1982-1987, Associate Prof. of Pharmacology with tenure, Univ. Missouri Sch. Med., Columbia, MO.

1983-1984, Visiting Associate Professor of Biochemistry, University of Virginia, Charlottesville, VA, with Dr. T.E. Thompson (Sabbatical).

1987-1989, Associate Professor of Pharmacology & Medicinal Chemistry and Pharmacology & Cell Biophysics, University of Cincinnati Medical Center

1989-1994, Professor of Pharmacology & Medicinal Chemistry and Pharmacology & Cell Biophysics with tenure, University of Cincinnati Medical Center

1994-1996, Professor of Physiology and Pharmacology, Texas A&M University, TVMC

1996-present, Professor of Physiology and Pharmacology with tenure, Texas A&M Univ., TVMC